Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic urticaria and infections.

Bettina Wedi1, Ulrike Raap, Alexander Kapp

  • 1Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany. Bettina_Wedi@t-online.de

Current Opinion in Allergy and Clinical Immunology
|September 7, 2004
PubMed
Summary

While infections can trigger acute hives, their causal role in chronic urticaria is uncertain. However, infections may exacerbate existing chronic hives in susceptible individuals, suggesting a complex immune response.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bullous Pemphigoid Needs Two Axes, not One: Refining the Actionable Inflammatory Endotype: Reply From Authors.

The British journal of dermatology·2026
Same author

Cutaneous Lymphangiosis Carcinomatosa in Lung Cancer.

Deutsches Arzteblatt international·2026
Same author

[Successful treatment of lupus erythematosus tumidus (LET) with deucravacitinib in a patient with concomitant plaque psoriasis].

Dermatologie (Heidelberg, Germany)·2026
Same author

Decoding allergy in vitro: Challenges and clinical use of humoral and cellular methods.

Allergologie select·2026
Same author

Prick tests and basophil activation tests in hypersensitivity to SARS-CoV-2 vaccines and components.

Allergologie select·2026
Same author

Expert consensus on the long-term use of lanadelumab in hereditary angioedema: Toward harmonized care.

Allergologie select·2026

Area of Science:

  • Dermatology
  • Immunology
  • Infectious Diseases

Background:

  • Chronic urticaria pathogenesis is complex and multifactorial, with a lack of specific treatments.
  • While acute urticaria often links to infections, the role of infections in chronic urticaria is debated, though they can worsen symptoms.

Purpose of the Study:

  • To review current peer-reviewed literature on the relationship between infections and chronic urticaria.
  • To analyze the evidence for infections as a cause or exacerbating factor in chronic urticaria.

Main Methods:

  • Systematic review of English-language publications.
  • Analysis of studies investigating infections in patients with chronic urticaria.

Main Results:

Related Experiment Videos

  • Evidence suggests infections may not increase in prevalence but can trigger chronic urticaria in susceptible individuals via immune responses.
  • A potential infection-associated autoreactive response exists, particularly in patients with positive autologous serum skin tests, possibly involving molecular mimicry.

    • Conclusions:

    • Evidence for a direct causal role of underlying infections in chronic urticaria is currently weak.
    • Establishing a definitive link between infections and chronic urticaria is challenging due to confounding factors and lack of challenge tests.
    • Future research should explore the interplay between urticaria, autoimmunity, non-IgE hypersensitivity, and infections to develop targeted therapies.