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Increased mitogen-induced lymphocyte proliferation in treatment resistant depression: a preliminary study
Marta Kubera1, Agnieszka Basta-Kaim, Andrzej Wróbel
1Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smêtna 12, 31-343 Kraków, Poland.
Background:
The biological basis of treatment resistance in depression still remains unclear. Some studies suggest that there exists a relationship between a disturbance in the immune system and depression.
Aims:
To investigate the immune status of patients with treatment resistant depression, we compared the in-vitro lymphocytic responses to three different mitogens in 10 drug-free patients with treatment resistant depression and 10 normal controls matched for age and sex.
Results:
We observed a marked increase in the lymphocyte mitogenic activity to mitogens of T lymphocytes.
Discussion:
This activation of lymphocyte function may be indicative of a pathological stimulation in cell-mediated immunity in patients with treatment resistant depression.