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Recent experience with ultrasonic tissue characterization.

R L Popp1

  • 1Division of Cardiovascular Medicine, Stanford University School of Medicine, California 94035.

The American Journal of Cardiology
|June 18, 1992
PubMed
Summary
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Cyclic variation of integrated ultrasonic backscatter (CVIBS) effectively characterizes cardiac tissue. This ultrasound technique shows reduced septal values in hypertrophy and detects acute rejection in cardiac allografts.

Area of Science:

  • Cardiovascular Ultrasound
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Ultrasonic tissue characterization is crucial for diagnosing cardiac conditions.
  • Cyclic variation of integrated ultrasonic backscatter (CVIBS) is a novel parameter derived from ultrasonic backscatter.
  • Prototype equipment allows measurement of relative changes in ultrasonic backscatter.

Purpose of the Study:

  • To evaluate the utility of CVIBS for cardiac tissue characterization.
  • To assess CVIBS in normal subjects, patients with cardiac hypertrophy, and human cardiac allografts.
  • To determine the interobserver reproducibility of CVIBS measurements.

Main Methods:

  • Utilized prototype ultrasound equipment to measure CVIBS.
  • Compared CVIBS values in the posterior wall and septum of normal subjects.

Related Experiment Videos

  • Analyzed CVIBS in patients with pressure overload hypertrophy and hypertrophic cardiomyopathy.
  • Applied CVIBS to monitor human cardiac allografts for acute rejection.

    • Main Results:

    • CVIBS demonstrated good interobserver reproducibility.
    • Septal CVIBS values were significantly lower in hypertrophy groups compared to normal subjects.
    • A characteristic decrease in CVIBS was observed during acute rejection of cardiac allografts.

    Conclusions:

    • CVIBS is a reliable parameter for ultrasonic tissue characterization.
    • CVIBS can differentiate between normal and hypertrophied cardiac tissue.
    • CVIBS shows potential for non-invasive detection of acute rejection in cardiac allografts.