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[Reconstruction of mandibular defect by using Titanium mandibular prosthesis: a preliminary experimental study].
Zheng-Xue Han1, Tong Ji, Chen-Ping Zhang
1Department of Oral Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology
|September 7, 2004
Summary
Titanium mandibular prostheses show potential for reconstruction, but successful osseointegration depends on preventing prosthesis exposure. Muscle reattachment is achievable with a "muscle-bone-prosthesis" model.
Area of Science:
- Biomaterials science
- Oral and maxillofacial surgery
- Regenerative medicine
Background:
- Mandibular defects pose reconstructive challenges.
- Titanium prostheses offer a potential solution for mandibular reconstruction.
Purpose of the Study:
- To investigate the applicability of titanium mandibular prostheses for reconstruction.
- To evaluate the healing and osseointegration of titanium prostheses in mandibular defects.
Main Methods:
- Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) was used to design titanium prostheses.
- Prostheses were implanted into mandibular defects in goats, with autogenic bone grafting for angle defects.
- Radiographic, histological, and biomechanical evaluations assessed healing and osseointegration.
Main Results:
- One body prosthesis experienced exposure and fixation failure; the other showed stable fixation despite exposure.
- Osseointegration was observed in the angle prosthesis and non-exposed areas of the body prosthesis.
- Muscle reattachment to the bone graft area was confirmed.
Conclusions:
- CAD/CAM titanium prostheses are applicable for mandibular reconstruction.
- Preventing prosthesis exposure is crucial for successful osseointegration.
- The "muscle-bone-prosthesis" model facilitates muscle reattachment.