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Fatal intoxication cases: cytochrome P450 2D6 and 2C19 genotype distributions

A L Zackrisson1, P Holmgren, A B Gladh

  • 1National Board of Forensic Medicine, Department of Forensic Genetics,, University Hospital, 581 85 Linköping, Sweden. annza@imv.liu.se

European Journal of Clinical Pharmacology
|September 7, 2004
PubMed
Summary

Individuals lacking the CYP2D6 enzyme, crucial for drug metabolism, were less frequent in fatal intoxication cases than expected. This suggests a protective effect against drug overdose in some individuals.

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