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Related Experiment Videos

Invasive growth: a genetic program.

Alessandra Gentile1, Paolo M Comoglio

  • 1IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy. alessandra.gentile@ircc.it

The International Journal of Developmental Biology
|September 7, 2004
PubMed
Summary

Hepatocyte Growth Factor (HGF) coordinates invasive growth, a process crucial for tissue repair and cancer metastasis. This review explores the biological aspects and intracellular signals regulating this complex cellular behavior.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Biology

Background:

  • Invasive growth involves cell dissociation, migration, matrix degradation, proliferation, and survival.
  • These processes are vital for tissue development, repair, and aberrant in cancer metastasis.
  • While cytokines and growth factors influence individual aspects, HGF uniquely coordinates the entire process.

Purpose of the Study:

  • To discuss the multifaceted biological roles of invasive growth.
  • To analyze the intracellular signaling pathways governing invasive growth.
  • To highlight the central role of Hepatocyte Growth Factor (HGF) and its receptor Met.

Main Methods:

  • Review of existing literature on invasive growth and HGF signaling.
  • Analysis of cellular and molecular mechanisms underlying invasive growth.

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  • Discussion of intracellular signal transduction pathways activated by HGF/Met.

    • Main Results:

    • Invasive growth is a complex program with diverse biological functions.
    • HGF, acting via the Met receptor tyrosine kinase, orchestrates invasive growth.
    • Specific intracellular signals mediate the various components of invasive growth.

    Conclusions:

    • HGF/Met signaling is a key regulator of coordinated invasive growth.
    • Understanding these pathways is crucial for both developmental biology and cancer research.
    • Further investigation into intracellular signals can reveal therapeutic targets for cancer metastasis.