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Organs transplanted from intoxicated donors.

E Duque1, J Duque, J Henao

  • 1Transplant Group, University of Antioquia, San Vicente de Paul University Hospital, Medellin, Colombia, South America. nefronsa@epm.net.co

Transplantation Proceedings
|September 8, 2004
PubMed
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Transplanting organs from deceased donors who died of poisoning is feasible. Kidney and liver transplant recipients showed good short-term and long-term graft survival rates, comparable to standard donor criteria.

Area of Science:

  • Transplantation immunology
  • Organ procurement
  • Toxicology

Background:

  • Cadaveric organ donation is crucial for addressing organ shortages.
  • The safety and efficacy of using organs from donors who died of poisoning remain areas of investigation.

Purpose of the Study:

  • To evaluate the short- and long-term outcomes of organ transplants from deceased donors who died due to various types of poisoning.
  • To assess graft survival rates and recipient complications in this specific donor population.

Main Methods:

  • Utilized the Kaplan-Meier method to calculate actuarial survival rates for organs from intoxicated donors.
  • Retrospectively analyzed data from January 1998 to December 2002, identifying donors with poisoning as the cause of brain death.

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Main Results:

  • Five donors (0.98%) died of poisoning (organophosphates, methanol, cyanide, acetylsalicylic acid), yielding 10 kidneys, 1 liver, 2 corneas, and 1 set of bones.
  • Kidney recipients showed 90% normal function at 3 months, with 90% and 80% actuarial survival at 12 and 24 months, respectively.
  • No delayed graft function, rejection, or signs of poisoning were observed in recipients; the liver recipient had a favorable outcome.

Conclusions:

  • Organ transplantation from deceased donors who died of poisoning is a viable option.
  • Graft survival rates in recipients of organs from poisoned donors are comparable to those from standard donor populations.