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14-3-3 Proteins--a focus on cancer and human disease

Erik Wilker1, Michael B Yaffe

  • 1Center for Cancer Research, Massachusetts Institute of Technology, E18-580, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Journal of Molecular and Cellular Cardiology
|September 8, 2004
PubMed

Insights

14-3-3 proteins are key regulators in eukaryotic cell signaling, controlling cell cycle and DNA damage. Their dysregulation is linked to human diseases like cancer, suggesting potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • 14-3-3 proteins are conserved phosphoserine/phosphothreonine-binding proteins crucial for eukaryotic cell signaling.
  • They regulate diverse cellular processes including cell cycle, DNA damage response, and apoptosis.
  • Dysregulation of 14-3-3 proteins is implicated in various human diseases, notably cancer.

Purpose of the Study:

  • To review the regulatory mechanisms of 14-3-3 protein structure and ligand binding.
  • To highlight the critical role of 14-3-3 proteins in human diseases, with an emphasis on cancer.
  • To explore the therapeutic potential of targeting 14-3-3 proteins.

Main Methods:

  • Literature review of 14-3-3 protein function and disease association.
  • Analysis of current data on 14-3-3 isotypes and their interactions.
  • Discussion of therapeutic strategies targeting 14-3-3 proteins.

Main Results:

  • 14-3-3 proteins modulate key signaling pathways through phosphorylation-dependent interactions.
  • Specific 14-3-3 isotypes interact with important proteins like Raf and Cdc25.
  • Aberrant 14-3-3 activity is a common feature in cancer development and progression.

Conclusions:

  • 14-3-3 proteins are vital regulators of cellular functions and disease pathogenesis.
  • Understanding 14-3-3 protein interactions offers insights into disease mechanisms.
  • Targeting 14-3-3 proteins presents a promising avenue for novel cancer therapies.

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