Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus

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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Jong-Moon Hur1, Chun-Ho Yang, Seung-Ho Han

  • 1Department of Oral Microbiology, School of Dentistry and WBMI, Wonkwang University, Iksan 570-749, South Korea.

Fitoterapia
|September 8, 2004
PubMed

Insights

Phellinus linteus mushroom extracts were tested for antibacterial effects. The n-butanol (n-BuOH) fraction demonstrated significant activity against methicillin-resistant Staphylococcus aureus.

Area of Science:

  • Mycology
  • Pharmacology
  • Microbiology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant global health threat.
  • Natural products, including medicinal mushrooms, are explored for novel antimicrobial agents.
  • Phellinus linteus is a traditional medicinal mushroom with various reported bioactivities.

Purpose of the Study:

  • To evaluate the antibacterial potential of Phellinus linteus fruit body extracts.
  • To identify which fractions exhibit the most potent activity against MRSA.

Main Methods:

  • Methanol extract of Phellinus linteus fruit body was prepared.
  • The extract was fractionated into chloroform (CHCl3), n-butanol (n-BuOH), and water (H2O) fractions.
  • Antibacterial activity was assessed against methicillin-resistant Staphylococcus aureus strains using minimum inhibitory concentration (MIC) assays.

Main Results:

  • The n-butanol (n-BuOH) fraction exhibited notable antibacterial activity.
  • The MIC values for the n-BuOH fraction ranged from 63 to 125 microg/ml against all tested MRSA strains.
  • Other fractions (CHCl3 and H2O) showed less pronounced activity.

Conclusions:

  • The n-BuOH fraction of Phellinus linteus possesses promising antibacterial properties against MRSA.
  • Phellinus linteus is a potential source for developing new therapeutic agents to combat MRSA infections.

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