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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
Strategies for hepatitis C therapeutic intervention: now and next
Seng-Lai Tan1, Yupeng He, Ying Huang
1Lilly Research Laboratories, Bldg 98A/2, Room 2105, Lilly Corporate Center, Indianapolis, IN 46285, USA. Tan_Seng-Lai@lilly.com
Abstract:
Interferon-alpha-based therapies are the mainstay of hepatitis C treatment. However, these broad immunomodulatory agents, already limited by their side effects, expense and route of administration, are not efficacious in all cases. Therefore, research efforts have focused on identifying additional drugs and therapeutic modalities to benefit those individuals refractive to current therapy, and which might be more affordable, such as orally active small-molecule alternatives and preventive or therapeutic vaccines. It is likely that successful therapeutic intervention of hepatitis C will require a combination of approaches targeting different aspects of the viral life-cycle.
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