Early postnatal Purkinje cells from staggerer mice undergo aberrant development in vitro with characteristic
L Thomas Shirley1, Anne Messer
1Department of Biomedical Sciences, University at Albany, Albany, NY 12203, United States.
Brain Research. Developmental Brain Research
|September 8, 2004
Abstract:
The staggerer (sg) mutant mouse shows an early block in Purkinje cell (PC) development due to a truncation of the transcription factor retinoic acid-related orphan receptor alpha (ROR alpha). Cerebellar cultures from neonatal sg mice recapitulate many in vivo postnatal changes in PCs and allow for detailed observation of sequential dendritic outgrowth and gene expression changes. In addition, this in vitro system provides a tractable basis for ROR alpha replacement studies.
