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Updated: Aug 13, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
Integrin and the Reelin-Dab1 pathway: a sticky affair?
1Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, Campus de San Juan s/n, E-03550 San Juan de Alicante, Alicante, Spain. luque@umh.es
Abstract:
It has been repeatedly suggested that integrin is essential for neuronal migration. A new study proposes a link between Disabled-1 (Dab1) phosphorylation and alpha3 integrin signalling that is thought to drive the timely detachment of migrating neurons from the guiding radial glia fibers during early corticogenesis. This proposal however is hardly compatible with time-lapse anatomical investigations and genetic studies on integrin or with recent works which indicate direct reelin signalling to radial fibers.
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