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Ferning test in Down's syndrome.

M Filipello1, G Scimone, G Cascone

  • 1Department of Ophthalmology, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.

Acta Ophthalmologica
|April 1, 1992
PubMed
Summary
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Tear ferning is altered in individuals with Down syndrome, affecting both eyes similarly. This tear film anomaly may contribute to frequent anterior eye infections in this population.

Area of Science:

  • Ophthalmology
  • Genetics
  • Biochemistry

Background:

  • Down syndrome is associated with various health complications, including ocular issues.
  • The tear film plays a crucial role in maintaining ocular surface health and preventing infections.

Purpose of the Study:

  • To investigate tear film ferning patterns in adults with Down syndrome.
  • To determine if tear film alterations in Down syndrome correlate with increased risk of anterior segment infections.

Main Methods:

  • The ferning test was used to evaluate tear film quality.
  • Tear film samples were collected from 56 eyes (28 subjects, 14 with Down syndrome, aged 18-35).
  • Tear ferning was assessed in both right and left eyes for each participant.

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Main Results:

  • Significant alterations in tear ferning patterns were observed in subjects with Down syndrome.
  • No significant difference in tear ferning was found between the right and left eyes of individuals.
  • The observed tear film anomaly suggests a potential link to ocular pathologies.

Conclusions:

  • Individuals with Down syndrome exhibit distinct tear film ferning abnormalities.
  • These tear film alterations may predispose individuals to recurrent infectious pathologies of the anterior eye segment.
  • Further research is warranted to elucidate the precise mechanisms and clinical implications.