Excitability changes in human hand motor area dependent on afferent inputs induced by different motor tasks

Using the technique of transcranial magnetic stimulation (TMS) with a figure-of-eight-shaped coil in 16 normal volunteers, we studied the extents of motor evoked potentials (MEPs) induced by remote facilitation of voluntary teeth clenching (VTC) and by motor imagery (MI). In particular, we examined whether different excitability changes in the primary motor cortex (M1) induced by both facilitation methods occur between early (I1 and I2) and late (I3 and I4) components of I-waves elicited from a first dorsal interosseous (FDI) muscle. Both components of I-waves were induced by anterior-medially (AM) directed currents or posterior-laterally (PL) directed currents. Our hypothesis was that facilitatory effects of VTC and MI on M1 differ because the neural pathways of these afferent inputs differ. The present results indicate that during MI MEP amplitudes of late components are significantly larger than those of early ones, although both MEP amplitudes are enhanced. On the other hand, during VTC MEP amplitudes of early components are significantly enhanced, but those of late ones are rather depressed. We conclude that recruitment of early and late components of I-waves differ depending on the afferent inputs to the motor cortex.