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Updated: Aug 12, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
Alternatively spliced annexin XI transcripts encode proteins that differ near the amino-terminus
C A Towle1, L Weissbach, B V Treadwell
1Orthopaedic Research Laboratories, Massachusetts General Hospital, Boston 02114.
Abstract:
Annexins are a family of structurally related calcium-dependent phospholipid binding proteins. We recently described a new member of this family, bovine annexin XI [1]. Two kinds of cDNAs were identified corresponding to annexin XI mRNA variants A and B, which are generated by alternative splicing of identical primary transcripts. Annexin XI isoforms are predicted to differ at the amino-terminus, suggesting that they may have distinct biological roles.
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