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Updated: Aug 22, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
The interaction of copper-bipyridyl complex with DNA and cleavage to DNA
Zhou-Sheng Yang1, Yan-Ling Wang, Guang-Chao Zhao
1School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P R, China. yzhoushe@mail.ahnu.edu.cn
Abstract:
The interaction of a copper-bipyridyl (bpy) complex with CT-DNA was investigated by voltammetry, absorption and fluorescence spectrophotometry. The binding constant of the Cu(bpy)2(2+) complex interacting with DNA was 3.24 x 10(4) L/mol and the ability binding of Cu(bpy)2(2+) to DNA was 1.3-times as large as that of Cu(bpy)2+ to DNA. DNA could be efficiently cleaved by a potential-modulated method in the presence of the Cu(bpy)2(2+) complex. The fragments of the cleaved DNA were separated by high-performance liquid chromatography (HPLC). The experimental results revealed that the proposed method for DNA cleavage is highly efficient.
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