The early story of coronary artery disease
1Department of Medicine, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica, West Indies.
Insights
Angina pectoris and coronary artery disease understanding evolved significantly from the late 18th century. Myocardial infarction recognition and its differentiation from angina occurred in the early 20th century.
Area of Science:
- Cardiology
- Medical History
Background:
- The historical understanding of cardiovascular conditions has evolved over centuries.
- Early medical descriptions laid the groundwork for modern diagnostics.
Observation:
- Angina pectoris was formally described in 1772.
- Coronary artery disease was identified as the underlying cause in 1779.
- Myocardial infarction pathology was recognized in 1912, with its distinction from angina clarified by the 1920s.
Findings:
- The historical timeline reveals a progressive understanding of ischemic heart diseases.
- Key milestones include the naming of angina, identification of its cause, and recognition of myocardial infarction.
Implications:
- Understanding this historical progression is crucial for appreciating the development of cardiovascular medicine.
- This historical context highlights the gradual scientific advancements in diagnosing and differentiating cardiac conditions.
Abstract:
Angina pectoris was first adequately described and named in 1772. However, coronary artery disease, as the cause, was noted in 1779. The pathology and clinical features of myocardial infarction were only recognized in 1912. The distinction between angina and infarction was clarified in the 1920s. Nitrate therapy remained the sole treatment until modern medical and surgical developments which this review does not cover.
Related Concept Videos
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary Artery Disease I: Introduction
Coronary Artery Disease II: Pathophysiology
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Acute Coronary Syndrome III: Diagnostic Studies
Angina I: Introduction


