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Published on: August 13, 2019
Use of norethisterone oenanthate and predisposition to thrombosis
Nasir Ali Afsar1, Qamaruddin Barakzai, Salman Naseem Adil
1Department of Pharmacology, Ziauddin Medical University, Karachi-75600. drnasirpk@yahoo.com
Objective:
To observe the effects of progestin-only hormonal contraceptives in our population.
Design:
Cohort study.
Place And Duration Of Study:
Department of Pharmacology, Ziauddin Medical University, Karachi and Department of Pathology, Faculty of Health Sciences, The Aga Khan University, Karachi from October 2002 to September 2003.
Patients And Methods:
The study comprised of 50 women of reproductive age group, divided into two equal and matched groups of 25 each, namely, a group of users of progestin-only injectable hormonal contraceptive Norethisterone oenanthate [NET EN] 200 mg used as a 2-monthly injection and a control group not using any hormonal contraception. Complete blood counts, prothrombin time (PT) and international normalized ratio (INR) as well as activated partial thromboplastin time (APTT) were monitored.
Results:
APTT and prothrombin time were not significantly different in both the groups. Menstrual irregularities were found out by more frequent in users of injectable hormonal contraceptives than in non-users (p= 0.001). Hemoglobin (p= 0.029) and hematocrit were slightly better preserved in the same group.
Conclusion:
Use of Norethisterone oenanthate does not predispose to thrombogenesis in current dose for contraception.
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