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Related Experiment Videos

Molecular mechanisms of NCAM function.

Anders M Hinsby1, Vladimir Berezin, Elisabeth Bock

  • 1Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, Panum Institute 6.2, Blegdamsvej 3, DK-2200, Denmark.

Frontiers in Bioscience : a Journal and Virtual Library
|September 9, 2004
PubMed
Summary

Neural cell adhesion molecule (NCAM) is a signaling receptor mediating cell-cell adhesion and responding to external cues. This review details NCAM

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Neural cell adhesion molecule (NCAM) traditionally viewed as a homophilic cell adhesion molecule (CAM).
  • NCAM is widely expressed in the nervous system.
  • Recent research reveals novel roles beyond simple cell adhesion.

Purpose of the Study:

  • To review NCAM function at the molecular level.
  • To discuss recent models of NCAM's extracellular ligand interactions.
  • To elucidate the intracellular signaling cascades initiated by NCAM.

Main Methods:

  • Literature review of recent research on NCAM.
  • Analysis of molecular mechanisms governing NCAM interactions.
  • Discussion of signaling pathways downstream of NCAM activation.

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Main Results:

  • NCAM functions as a signaling receptor, not just an adhesion molecule.
  • NCAM responds to both homophilic and heterophilic binding events.
  • NCAM-mediated signaling influences cellular outcomes like neurite outgrowth.

Conclusions:

  • NCAM's role has evolved from a simple CAM to a complex signaling hub.
  • Understanding NCAM's molecular interactions is key to deciphering its diverse functions.
  • NCAM signaling pathways are critical regulators of neuronal development and function.