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Updated: Aug 4, 2026

Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis
Published on: May 9, 2012
Semi-skeletonized internal mammary artery grafts and sternal wound complications
Yongzhi Deng1, Karen Byth, Hugh S Paterson
1Department of Cardiothoracic Surgery, Westmead Hospital, Australia.
Insights
This study identified risk factors for sternal wound complications after coronary artery surgery. Peripheral vascular disease, diet-controlled diabetes, and delayed sternal closure were key risks for overall complications.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Surgical Infections
Background:
- Sternal wound complications are a significant concern following coronary artery bypass grafting (CABG).
- The use of bilateral internal mammary arteries (BIMA) is common, but its association with sternal complications requires evaluation.
- Understanding risk factors is crucial for preventing sternal wound complications.
Purpose of the Study:
- To identify independent risk factors for sternal wound complications after myocardial revascularization using bilateral semi-skeletonized internal mammary arteries.
- To compare the sternal wound complication rate of this technique with other harvesting methods.
Main Methods:
- Prospective analysis of 751 patients undergoing coronary artery surgery from September 1994 to August 2002.
- Data collected included patient demographics, comorbidities, surgical details, and postoperative outcomes.
- Statistical analysis was performed to identify independent risk factors for sternal wound complications and sternal infection.
Main Results:
- Overall sternal wound complications occurred in 5.9% of patients.
- Independent risk factors for any sternal wound complication included peripheral vascular disease, diet-controlled diabetes, and delayed sternal closure.
- Independent risk factors for sternal infection were diabetes, postoperative pulmonary complications, and postoperative stroke.
- The complication rate using bilateral semi-skeletonized internal mammary artery conduits was comparable to other techniques.
Conclusions:
- Peripheral vascular disease, diet-controlled diabetes, and delayed sternal closure are significant risk factors for sternal wound complications after CABG.
- Diabetes, postoperative pulmonary complications, and stroke increase the risk of sternal infection.
- Bilateral semi-skeletonized internal mammary artery grafting demonstrates a comparable sternal wound complication rate to other methods.
Abstract:
This study aimed to evaluate the risk factors for sternal wound complications in patients undergoing myocardial revascularization using bilateral semi-skeletonized internal mammary arteries. Prospectively collected data on 751 patients undergoing coronary artery surgery from September 1994 to August 2002 were analyzed. The mean age of the patients was 56 years, 633 (84%) were male, 44 (6%) were over 66 years of age, and 170 (23%) were diabetic. Forty-four (5.9%) patients developed sternal wound complications. Among these cases, sternal infection occurred in 22 (2.9%) patients, of which 15 (2.0%) had sternal infection with mediastinitis and 7 (0.9%) had sternal infection alone. Independent risk factors for any sternal wound complications were peripheral vascular disease, diet-controlled diabetes, and delayed sternal closure. The risk factors for sternal infection were diabetes, postoperative pulmonary complications, and postoperative stroke. The perioperative mortality rate was 1.5% (11 patients), including 2 patients who had sternal wound complications. The use of bilateral semi-skeletonized internal mammary artery conduits carries a comparable sternal wound complication rate as conduits harvested by other techniques.
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