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Updated: Aug 22, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
A computational tool based on voxel geometry for dose reconstruction of a radiological accident due to external
A Lemosquet1, I Clairand, L de Carlan
1External Dosimetry Department, DRPH/SDE, Institute for Radiological Protection and Nuclear Safety-IRSN, Radiological Protection and Human Health Division, B.P. 17, F-92262 Fontenay-aux-Roses, France.
Abstract:
In the case of overexposure to ionising radiation, estimation of the absorbed dose in the organism is an important indicator for evaluating the biological consequences of this exposure. The physical dosimetry approach is based either on real reconstruction of the accident, using physical phantoms, or on calculation techniques. Tools using Monte Carlo simulations associated with geometric models are very powerful since they offer the possibility to simulate faithfully the victim and the environment for dose calculations in various accidental situations. Their work presents a new computational tool, called SESAME, dedicated to dose reconstruction of radiological accidents based on anthropomorphic voxel phantoms built from real medical images of the victim in association with the MCNP Monte Carlo code. The utility was, as a first step, validated for neutrons by experimental means using a physical tissue-equivalent phantom.
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