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Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions

Sabine Yerly, Huldrych F Günthard, Catherine Fagard

    AIDS (London, England)
    |September 9, 2004
    PubMed

    In HIV-1-infected patients with long-term undetectable viraemia on highly active antiretroviral treatment (HAART), we found that pre-HAART plasma viraemia and the baseline proviral DNA level were significantly associated with the viraemia setpoint during scheduled treatment interruptions. In long-term treated patients, pre-HAART viraemia may not be available, and in these circumstances proviral DNA, measured at the time of scheduled treatment interruption, can help to identify patients likely to reach a low viraemia setpoint after treatment interruption.

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