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Related Experiment Videos

Pet models in cancer research: general principles.

A Porrello1, P Cardelli, E P Spugnini

  • 1Molecular Oncogenesis Lab, Dept of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy. porrello@ifo.it

Journal of Experimental & Clinical Cancer Research : CR
|September 10, 2004
PubMed
Summary

Companion animals, like cats and dogs, are increasingly vital in oncology research due to shared tumor similarities with humans. Utilizing pet models offers a valuable translational research approach for developing new cancer therapies.

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Area of Science:

  • Comparative oncology
  • Translational cancer research

Background:

  • Oncology has advanced significantly over 50 years, utilizing various models for cancer study.
  • Animal investigations have been crucial in understanding cancer and discovering therapies.
  • The efficacy and side effects of preclinical cancer models remain a subject of debate.

Purpose of the Study:

  • To review the role and increasing importance of pet models in cancer research.
  • To highlight the histopathological, anatomical, genetic, and biomolecular similarities between pet and human tumors.
  • To discuss the ethical, clinical, and financial aspects of using pet models in translational research.

Main Methods:

  • Review of existing literature on pet models in oncology.
  • Examination of ethical, clinical, and financial considerations in translational research.

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  • Discussion of the potential of pet cancer registries and genome projects.

    • Main Results:

    • Pet models (feline, canine) exhibit significant similarities to human tumors, enhancing their value in cancer research.
    • The use of companion animals in clinical trials offers a societal added value through improved animal health.
    • New research roles, such as laboratory-clinic interface experts, are emerging in this field.

    Conclusions:

    • Pet models offer a promising avenue for preclinical cancer research due to shared biological characteristics with humans.
    • The adoption of pet models in tumor studies is supported by ethical, clinical, and financial arguments.
    • Further development of pet cancer registries and genome projects can enhance their utility in oncology.