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Published on: June 14, 2020
Molecularly imprinted polymers: a new tool for separation of steroid isomers
Michał Szumski1, Bogusław Buszewski
1Department of Environmental Chemistry and Ecoanalytics, Faculty of Chemistry, Nicolas Copernicus University, ul Gagarina 7, 87-100 Toruri, Poland.
Abstract:
Molecularly imprinted polymers hold great promise for the separation of chiral compounds. A non-covalent approach to the synthesis of MIPs relies on the presence of specific and non-specific interactions, which lead to the formation of a molecular imprint. The structural differences between 17-alpha-estradiol and 17-beta-estradiol are too small to permit their efficient separation on a MIP prepared with beta-estradiol as a template. Molecular modeling revealed the presence of only one hydrogen bond that differentiates the two isomers.
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