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Updated: Jul 25, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Backbone thioester exchange: a new approach to evaluating higher order structural stability in polypeptides.

Matthew G Woll1, Samuel H Gellman

  • 1Department of Chemistry, University of Wisconsin--Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|September 10, 2004
PubMed
Summary

Researchers replaced an amide bond with a dynamic thioester in bovine pancreatic polypeptide (bPP). This allows for reversible backbone thioester exchange (BTE), enabling studies on peptide structural stability and noncovalent interactions.

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