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Related Experiment Videos

Tissue-engineered injectable bone regeneration for osseointegrated dental implants.

Yoichi Yamada1, Minoru Ueda, Takahito Naiki

  • 1Center for Genetic and Regenerative Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Clinical Oral Implants Research
|September 10, 2004
PubMed
Summary

Injectable tissue-engineered bone using dog mesenchymal stem cells (dMSCs) and platelet-rich plasma (PRP) shows promising results for dental implant osseointegration. This dMSCs/PRP combination demonstrated significant bone-implant contact and density, comparable to traditional bone grafts.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Oral and Maxillofacial Surgery

Background:

  • Dental implant success relies on osseointegration, the direct contact between bone and implant.
  • Bone defects often require grafting materials to achieve sufficient bone volume and quality for implant stability.
  • Tissue-engineered bone constructs offer a potential alternative to traditional bone grafts.

Purpose of the Study:

  • To evaluate the efficacy of an injectable tissue-engineered bone composed of dog mesenchymal stem cells (dMSCs) and platelet-rich plasma (PRP) for promoting osseointegration in a canine mandible model.
  • To compare the osseointegration outcomes of dMSCs/PRP with PRP alone, autogenous particulate cancellous bone and marrow (PCBM), and a control group (defect only).

Main Methods:

  • Mandibular bone defects were created in dogs and grafted with dMSCs/PRP, PRP, PCBM, or left as a control.

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  • Dental implants were placed into the defects after a 2-month healing period.
  • Histological and histometric analyses were performed 2 months post-implantation to assess bone formation, neovascularization, marginal bone level, bone-implant contact (BIC), and bone density.

    • Main Results:

    • The dMSCs/PRP group exhibited well-formed mature bone and significant neovascularization, outperforming the control and PRP groups.
    • Higher marginal bone levels were observed around implants in the dMSCs/PRP, PCBM, and PRP groups compared to the control.
    • The dMSCs/PRP group showed significantly higher bone-implant contact (BIC) and bone density compared to the control group, with outcomes comparable to the PCBM group.

    Conclusions:

    • Injectable dMSCs/PRP is a viable option for bone regeneration in dental implant applications.
    • The combination of dMSCs and PRP promotes enhanced osseointegration, evidenced by improved BIC and bone density.
    • This tissue-engineered approach offers comparable results to autogenous bone grafting, suggesting its potential clinical applicability.