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Outbreak in France of Neisseria meningitidis B:15:P1.12 belonging to sequence type 1403

C Grodet1, P F Dequin, S Watt

  • 1Service de Bactériologie et Hygiène Hospitalière, Hôpital Trousseau, Tours, France.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|September 10, 2004
PubMed

Insights

A meningococcal disease outbreak in France involved a specific Neisseria meningitidis strain (ST-1403) affecting eight young adults. Purpura was prevalent in all cases, with outcomes similar to other meningococcal disease cases.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Microbiology

Background:

  • A meningococcal disease outbreak occurred in France between November 2000 and February 2002.
  • The outbreak was caused by a specific strain of Neisseria meningitidis: B:15:P1.12, sequence type 1403.

Purpose of the Study:

  • To describe the characteristics of a meningococcal outbreak caused by Neisseria meningitidis B:15:P1.12.
  • To analyze the epidemiological and clinical features of affected patients.

Main Methods:

  • Epidemiological typing was used to confirm a single strain responsible for the outbreak.
  • Clinical data from affected patients were analyzed.

Main Results:

  • Eight young patients (aged 14-28 years) were affected by this specific meningococcal strain.
  • Purpura was observed in all eight cases.
  • Outcomes (favorable, sequelae, death) were similar to other meningococcal disease cases in France during the period, but the affected age group was significantly younger than the median age (60.4 years) for other strains.

Conclusions:

  • The Neisseria meningitidis B:15:P1.12 (ST-1403) strain caused an outbreak primarily affecting young adults.
  • The high prevalence of purpura in this outbreak warrants further investigation.
  • This strain's predilection for a younger demographic contrasts with other meningococcal strains circulating in the region.

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