Increase of resistance to macrolides in invasive Streptococcus pneumoniae in Spain (2000-2001)

Area of Science:

• Medical Microbiology
• Infectious Diseases
• Public Health

Background:

• Invasive Streptococcus pneumoniae infections pose a significant public health threat.
• Monitoring antimicrobial resistance patterns is crucial for effective treatment strategies.
• The European Antimicrobial Resistance Surveillance System (EARSS) collects vital data on resistance trends.

Purpose of the Study:

• To analyze antimicrobial resistance trends of invasive Streptococcus pneumoniae isolates in Spain.
• To assess changes in resistance to penicillin and erythromycin between 2000 and 2001.
• To identify specific patient groups or laboratory participation patterns associated with increased resistance.

Main Methods:

• Analysis of 1,278 invasive Streptococcus pneumoniae isolates collected from 41 Spanish laboratories.
• Data collected through the European Antimicrobial Resistance Surveillance System (EARSS) during 2000-2001.
• Susceptibility testing performed using individual laboratory methods with annual external quality assessment.

Main Results:

• A significant increase in resistance to penicillin and erythromycin was observed between 2000 and 2001.
• This resistance increase was particularly evident in isolates from laboratories participating in both years.
• Isolates from pediatric and elderly patients showed a more noticeable rise in resistance.

Conclusions:

• Urgent attention is needed to address the rising antimicrobial resistance of Streptococcus pneumoniae in Spain.
• The findings highlight the importance of continuous surveillance and quality assessment in resistance monitoring.
• Targeted interventions may be necessary for vulnerable populations like children and the elderly.