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Bronchial hyperresponsiveness in children with atopic rhinitis: a 7-year follow-up

F Cibella1, G Cuttitta, S La Grutta

  • 1Istituto di Biomedicina e Immunologia Molecolare del C.N.R., Palermo, Italy.

Allergy
|September 10, 2004
PubMed

Insights

Children with allergic rhinitis have high bronchial hyperresponsiveness (BHR). However, their asthma development risk is low, with normal peak expiratory flow variability, suggesting BHR in allergic rhinitis may not predict asthma.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Research

Background:

  • Allergic rhinitis (AR) is common in atopic individuals.
  • Bronchial hyperresponsiveness (BHR) is prevalent in atopic rhinitis patients.
  • BHR may indicate an increased risk for developing bronchial asthma.

Purpose of the Study:

  • To evaluate BHR and atopy in non-asthmatic children with AR over 7 years.
  • To determine the role of BHR and atopy in the development of asthma in this cohort.

Main Methods:

  • Twenty-eight children (6-15 years) with AR were enrolled.
  • Evaluated atopy via skin tests and total serum IgE.
  • Assessed BHR using methacholine bronchial challenge (PD(20)FEV(1), D(RS)) and peak expiratory flow (PEF) variability.
  • Follow-up assessment after 7 years using identical criteria.

Main Results:

  • At baseline, 46% of children had BHR (Mch+), with normal PEF variability.
  • No children with a negative methacholine test developed asthma.
  • After 7 years, only 2 of 13 children with BHR reported asthma symptoms.

Conclusions:

  • Children with allergic rhinitis exhibit a high prevalence of BHR.
  • Despite BHR, peak expiratory flow variability remains normal in these children.
  • The rate of asthma development in children with allergic rhinitis and BHR is low.
Abstract

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