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[Clinical study on changes of heme oxygenase-1 expression in patients with acute myocardial infarction]

Song-ming Chen1, Yu-guang Li, Dong-ming Wang

  • 1Department of Cardiology, First Affiliated Hospital of Medical College, Shantou University, Shantou 515041, Guangdong, China. csm1002@126.com

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue
|September 10, 2004
PubMed

Insights

Heme oxygenase-1 (HO-1) protein expression is significantly elevated in patients experiencing acute myocardial infarction. Conversely, individuals with normal coronary arteries exhibit lower HO-1 levels, suggesting its role in myocardial infarction.

Area of Science:

  • Biochemistry
  • Cardiology
  • Immunology

Background:

  • Heme oxygenase-1 (HO-1) is an enzyme involved in heme catabolism.
  • HO-1 plays a role in cellular protection against oxidative stress.
  • Changes in HO-1 expression may be linked to cardiovascular diseases.

Purpose of the Study:

  • To investigate the expression levels of heme oxygenase-1 (HO-1) in patients diagnosed with acute myocardial infarction.
  • To compare HO-1 expression in acute myocardial infarction patients with those having coronary heart disease but no acute event, and healthy controls.

Main Methods:

  • Inclusion of 45 acute myocardial infarction patients, 50 coronary heart disease patients (without acute myocardial infarction), and 40 healthy controls.
  • Isolation of monocytes and lymphocytes from patient blood samples.
  • Quantification of HO-1 protein expression using immunohistochemistry, Western blot, and a computer picture analyzing system.

Main Results:

  • HO-1 protein expression was localized to the cytoplasm.
  • Significantly higher HO-1 protein expression levels were observed in acute myocardial infarction patients compared to those without (P<0.01).
  • Lower HO-1 protein expression levels were found in patients with normal coronary arteries.

Conclusions:

  • Acute myocardial infarction is associated with increased heme oxygenase-1 (HO-1) protein expression.
  • Normal coronary arteries correlate with reduced HO-1 protein expression.
  • HO-1 may serve as a potential biomarker in acute myocardial infarction.
Abstract

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