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[Expression of a plant associated human cancer antigen in breast cancer]
Jun Fu1, Hai-mei Tian, Ping Qu
1Medical Center for Tumor Detection, Cancer Institute (Hospital), Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021, China.
Objective:
To study the expression of a glycoprotein of plant origin in normal, benign and malignant breast tissues.
Methods:
Expression of a plant glycoprotein was examined in 5 samples of normal breast tissues, 20 fibro-adenoma and 136 breast cancer by SABC immunohistochemical staining and the results were analyzed by SPSS statistics software.
Results:
No positive staining was detected in normal breast tissues (0/5). Weak staining was observed in 4 of 20 (20.0%) breast fibro-adenoma. Positive staining was demonstrated in 116 out of 136 (85.3%) breast cancer specimens. The differences were statistically significant. The expression of plant-associated human cancer antigen was related to pathological grade (P < 0.05), tissue invasiveness (P < 0.01) and recurrence (P < 0.05), but not to patients' age, tumor size and c-erbB-2 expression.
Conclusion:
The plant glycoprotein studied may be a human cancer-associated antigen which might be a potential marker of breast cancer.
