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Related Experiment Videos

Thy-1: more than a mouse pan-T cell marker.

S M Mansour Haeryfar1, David W Hoskin

  • 1Cellular Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. mhaeryfar@niaid.nih.gov

Journal of Immunology (Baltimore, Md. : 1950)
|September 10, 2004
PubMed
Summary
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Thy-1 (CD90) plays a dual role in T cell activation. It can substitute for T cell receptor signaling or enhance T cell responses when combined with T cell receptor triggering, suggesting roles in T cell homeostasis.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Thy-1 (CD90) is a GPI-anchored protein abundant on mouse thymocytes and T cells.
  • Its role in T lymphocyte activation is suggested by cross-linking studies, but a physiological ligand is unknown.

Purpose of the Study:

  • To investigate the function of Thy-1 in T cell activation.
  • To explore Thy-1's signaling capacity in conjunction with other T cell co-stimulatory pathways.

Main Methods:

  • Utilized monoclonal antibodies (mAbs) for Thy-1 cross-linking.
  • Examined T cell proliferation and cytokine synthesis.
  • Assessed T cell activation in the context of CD28 and T cell receptor (TCR) signaling.

Main Results:

  • Thy-1 cross-linking, with CD28 costimulation, can substitute for TCR signaling in T cell activation.

Related Experiment Videos

  • Thy-1 cross-linking potently costimulates T cells already activated via the TCR.
  • Identified a dual signaling capacity for Thy-1.

    • Conclusions:

    • Thy-1 may contribute to T cell homeostasis independently of TCR triggering.
    • Thy-1 signaling can potentiate antigen-induced T cell responses.
    • Further research is needed to identify Thy-1's physiological ligand in lymphoid tissues.