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Related Experiment Videos

TOR pathway: linking nutrient sensing to life span.

Pankaj Kapahi1, Brian Zid

  • 1Buck Institute for Age Research, Novato, CA 94945, USA. Pkapahi@buckinstitute.org

Science of Aging Knowledge Environment : SAGE KE
|September 10, 2004
PubMed
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The target of rapamycin (TOR) pathway influences how nutrients affect lifespan. This pathway interacts with insulin signaling and regulates key processes impacting longevity.

Area of Science:

  • Molecular biology
  • Gerontology
  • Nutrient signaling

Background:

  • The target of rapamycin (TOR) pathway is increasingly recognized for its role in aging.
  • Nutrient availability significantly impacts lifespan across species.
  • Understanding signaling pathways involved in aging is crucial for developing interventions.

Purpose of the Study:

  • To explore the role of the TOR pathway in mediating nutrient-dependent lifespan regulation.
  • To discuss the interplay between TOR and insulin-like signaling pathways.
  • To identify key downstream processes regulated by TOR.

Main Methods:

  • Literature review and synthesis of recent studies on TOR signaling and lifespan.
  • Analysis of molecular mechanisms linking nutrient sensing to aging.

Related Experiment Videos

  • Discussion of pathway interactions and downstream effectors.

    • Main Results:

    • The TOR pathway emerges as a key modulator of lifespan in response to nutrient cues.
    • TOR signaling interacts with insulin-like signaling pathways to influence aging processes.
    • TOR regulates critical downstream cellular processes relevant to longevity.

    Conclusions:

    • The TOR pathway is a central regulator of nutrient-dependent lifespan.
    • Interactions between TOR and insulin signaling are critical for lifespan regulation.
    • Targeting TOR-regulated pathways may offer strategies to modulate aging.