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Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet.

A Lingenhel1, C Eder, K Zwiauer

  • 1Institute of Medical Biology and Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
|September 10, 2004
PubMed
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Plasma apolipoprotein A-IV (apoA-IV) significantly decreases in obese adolescents after weight loss. This reduction in apoA-IV levels is not directly linked to the amount of weight lost.

Area of Science:

  • Endocrinology
  • Nutrition Science
  • Cardiovascular Research

Background:

  • Apolipoprotein (apo) A-IV is recognized for its antiatherogenic properties and potential role in regulating food intake.
  • Elevated plasma apoA-IV levels are observed in human obesity, with polymorphisms linked to obesity severity.

Purpose of the Study:

  • To investigate the impact of weight loss on plasma apoA-IV levels in obese adolescents.
  • To explore the relationship between apoA-IV levels and the degree of obesity before and after intervention.

Main Methods:

  • A longitudinal intervention study involving a low-fat, hypocaloric diet in a dietary camp setting.
  • Two groups of obese adolescents (n=47 and n=29) participated, with measurements taken before and after a 3-week weight reduction period.

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Main Results:

  • Plasma apoA-IV levels decreased significantly from baseline in both groups following weight reduction (P<0.001).
  • The relative proportion of lipid-free apoA-IV and apoA-IV associated with apoA-I showed a slight increase.
  • Changes in plasma apoA-IV did not correlate independently with relative body mass index, weight loss, or plasma leptin levels.

Conclusions:

  • Plasma apoA-IV concentrations markedly decrease in overweight adolescents during short-term weight reduction.
  • The observed reduction in apoA-IV is not directly proportional to the extent of weight loss, suggesting complex underlying mechanisms.