Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Steric complementarity in carboxylate anion recognition.

Jane Nelson1, Mark Nieuwenhuyzen, Ibolya Pál

  • 1School of Biomedical Sciences, University of Ulster Coleraine, BT52 1SA, UK. j.nelson@ulster.ac.uk

Dalton Transactions (Cambridge, England : 2003)
|September 10, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atypical B cells and inflammatory profiles delineate immunity to influenza vaccination in First Nations and non-Indigenous people with chronic multimorbidity.

Nature communications·2026
Same author

In situ evaluation of an active-passive sampling (APS) technique for monitoring psychoactive compounds in effluent wastewater.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Systematic assessment of the mechanisms and risks of micro- and nanoplastic particle exposure in marine invertebrates.

Ecotoxicology and environmental safety·2026
Same author

Beyond growth: comparative impact of plastics and natural particles on EPS dynamics and aggregation in Rhodomonas Salina.

Scientific reports·2025
Same author

Sorption of psychoactive compounds on passive sampling sorbents in the presence of wastewater suspended particulate matter.

Environmental pollution (Barking, Essex : 1987)·2025
Same author

Cellular and tissue-level responses of mussels (Mytilus edulis) to aged polyethylene terephthalate (PET) micro- and nanoplastic particles.

Aquatic toxicology (Amsterdam, Netherlands)·2025

A novel pyridino-linked aminocryptand effectively binds carboxylate anions like oxalate. At high protonation, it forms dimeric units via hydrogen bonds, utilizing a cleft-binding mode.

Area of Science:

  • Supramolecular Chemistry
  • Anion Recognition

Background:

  • Aminocryptands are known for their ability to host various anions within their cavities.
  • The specific binding modes and affinities of pyridino-linked aminocryptands, especially with carboxylates, require further investigation.

Purpose of the Study:

  • To investigate the host-guest chemistry of a 2,6 pyridino-linked aminocryptand with carboxylate anions.
  • To determine the complexation constants and binding modes of the host with different carboxylates in aqueous solution.
  • To elucidate the structural basis of anion binding, particularly at different protonation states of the host.

Main Methods:

  • Synthesis and characterization of the 2,6 pyridino-linked aminocryptand.
  • Determination of aqueous complexation constants for various carboxylate anions (oxalate, malonate, acetate, lactate).

Related Experiment Videos

  • X-ray crystallography to analyze the solid-state structure of the host-oxalate complex at a high protonation level.

    • Main Results:

    • The pyridino-linked aminocryptand demonstrates effective binding of carboxylate anions at low protonation levels.
    • Complexation constants indicate good affinity for oxalate, malonate, acetate, and lactate.
    • At the hexaprotonated level, complexation with oxalate leads to the formation of a dimeric unit.
    • The crystal structure reveals a short hydrogen bond (2.474 Å) between the host and oxalate/semioxalate.
    • The protonated cryptand adopts a cleft-binding mode, distinct from the cavity-binding mode of other aminocryptands.

    Conclusions:

    • The 2,6 pyridino-linked aminocryptand is a versatile host for carboxylate anions.
    • Protonation state significantly influences the binding mode and self-assembly of the host-anion complex.
    • The observed cleft-binding mode offers a new perspective on anion recognition by cryptand hosts.