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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Staphylococcus aureus with reduced susceptibility to vancomycin

S E Cosgrove1, K C Carroll, T M Perl

  • 1Division of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. scosgro1@jhmi.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|September 10, 2004
PubMed

Insights

Vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-intermediate S. aureus (VISA) infections are increasing. This review covers definitions, risk factors, detection, and management strategies for these challenging infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Rising incidence of Staphylococcus aureus infections with reduced vancomycin susceptibility.
  • Emergence of vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) necessitates updated guidance.

Purpose of the Study:

  • To define VISA and VRSA and identify associated risk factors.
  • To elucidate mechanisms of vancomycin resistance in S. aureus.
  • To detail laboratory detection methods and discuss infection control and management.

Main Methods:

  • Literature review of definitions, risk factors, resistance mechanisms, detection methods, and clinical management.
  • Synthesis of current knowledge on VISA and VRSA.

Main Results:

  • Clear definitions provided for VISA and VRSA.
  • Key risk factors and mechanisms of resistance are outlined.
  • Laboratory detection strategies and infection control measures are discussed.

Conclusions:

  • Effective management of VISA and VRSA requires understanding resistance mechanisms and implementing robust infection control.
  • Early detection and appropriate treatment are crucial for improving patient outcomes and preventing spread.

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