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K103N mutation in antiretroviral therapy-naive African patients infected with HIV type 1
Omobosola Akinsete1, Diane Hirigoyen, Charles Cartwright
1Department of Infectious Diseases, University of Minnesota/Hennepin County Medical Center, Minneapolis, Minnesota 55455, USA. BosolaA@aol.com
Abstract:
Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non-subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.
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