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Published on: May 29, 2020
IgA-dominant glomerulonephritis associated with hepatitis A
S R Cheema1, F Arif, D Charney
1Division of Nephrology, St. Luke's-Roosevelt Hospital Center, College of P&S of Columbia University, New York, NY, USA. shafiqcheema@yahoo.com
Abstract:
Unlike hepatitis B and C, renal involvement has been extremely uncommon in patients with hepatitis Avirus (HAV) infection. Nephrotic syndrome has been documented as a rare complication in association with HAV infection. In this report, we describe a patient with serologically documented HAV infection, who presented with nephrotic syndrome. The renal biopsy showed an immunoglobulin A- (IgA) dominant glomerulonephritis (GN) with subendothelial immune deposits. This is the second biopsy-proven case report of a patient with acute HAV associated with IgA-dominant immune complex glomerulonephritis and nephrotic syndrome. This is perhaps the first case in which a patient experienced both IgA-dominant glomerulonephritis and cutaneous cryoglobulinemic vasculitis.
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