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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Influences on childhood height: comparing two generations in the 1958 British birth cohort
1Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. L.Li@ich.ucl.ac.uk
Insights
Environmental influences on childhood height have decreased between recent generations in Great Britain. While parental genetics remain a strong predictor, factors like socioeconomic status have a weaker impact on offspring height.
Area of Science:
- Human growth and development
- Pediatric health
- Sociogenetics
Background:
- Genetics and early life environment are established determinants of human height.
- Limited data exists on how these influences evolve across generations.
Purpose of the Study:
- To investigate changes in the determinants of childhood height between two generations in Great Britain.
- To compare the impact of genetic and environmental factors on height across generations.
Main Methods:
- Utilized data from the 1958 British birth cohort study and their offspring (1991).
- Measured childhood height (standard deviation scores) at ages 7 (cohort) and 4-18 (offspring).
- Employed multilevel models to account for family structure in height analysis.
Main Results:
- Childhood height increased by 1 cm in the offspring generation compared to the 1958 cohort.
- Parental height remained the strongest predictor of childhood height in both generations.
- Adverse environmental influences (e.g., maternal smoking, socioeconomic factors) showed diminished effects in the younger generation.
Conclusions:
- The impact of adverse environmental factors on childhood height has significantly reduced between recent generations in Great Britain.
- Genetic factors, specifically parental height, continue to be the primary driver of childhood height.
Background:
Genetics and early environment are known to influence height, but evidence is sparse on changes in these influences over time.
Methods:
The 1958 British birth cohort study includes all children born between March 3, 1958 and March 9, 1958, who were followed to age 41 yr, and one-third of their offspring in 1991. Childhood height in each generation (measured at 7 yr for cohort members and 4-18 yr for offspring) was converted to a standard deviation score based on the 1990 British growth reference. We used multilevel models to analyse influences on height in order to allow for the hierarchical within-family data structure.
Results:
Childhood height increased by 1 cm between 1958 cohort members and their offspring. Several influences on childhood height in the older generation (maternal smoking, breastfeeding, maternal age, social class, maternal education, and parental divorce) did not affect childhood height in the younger generation. Parental height was most strongly associated with childhood height and effects did not diminish between generations [adjusted increase approximately 2 cm for 1 maternal or paternal height standard deviation score (SDS)]. Third- or later-borns and those with three or more siblings had deficits of 1-2 cm (adjusted estimates) in both generations. Other factors, particularly indicators of socioeconomic position, showed weaker effects in the younger generation. For example, the growth deficit of 1.1 cm (adjusted estimate) among cohort members from households with >1.5 persons/room had disappeared in the offspring.
Conclusions:
Within Great Britain, the adverse effects of environmental factors on childhood height have lessened between recent generations.
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