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Multiple myeloma: appearance at MR imaging.

H I Libshitz¹, S R Malthouse, D Cunningham

¹Department of Radiology, Royal Marsden Hospital, Sutton, England.

|March 1, 1992

Summary

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Magnetic resonance (MR) imaging reveals vertebral abnormalities in multiple myeloma patients. T2-weighted images are often superior for detecting focal tumor lesions compared to T1-weighted scans.

Area of Science:

Radiology
Oncology
Hematology

Background:

Multiple myeloma is a hematologic malignancy affecting plasma cells.
Accurate staging and assessment of disease burden are crucial for treatment planning.
Magnetic resonance (MR) imaging offers detailed visualization of the skeletal system.

Purpose of the Study:

To evaluate the utility of MR imaging in assessing lumbar spine involvement in multiple myeloma.
To compare the effectiveness of T1- and T2-weighted sequences in detecting myeloma-related lesions.

Main Methods:

Retrospective review of MR imaging examinations of the lumbar spine in 32 patients with multiple myeloma.
Analysis of T1- and T2-weighted images for signal intensity (SI) variations and focal lesions.

Related Experiment Videos

Correlation of MR imaging findings with clinical, laboratory, and bone marrow data.

Main Results:

Vertebral SI varied on T1- and T2-weighted images, with foci of decreased or increased SI noted in a significant proportion of patients.
Abnormal SI consistent with tumor was identified in 50% of vertebral compression fractures.
T2-weighted images demonstrated focal tumor lesions better or exclusively in 65% of cases with identifiable focal disease.
No significant correlation was found between MR imaging findings and laboratory or bone marrow results.

Conclusions:

MR imaging is valuable for evaluating lumbar spine involvement in multiple myeloma.
T2-weighted sequences are more sensitive for detecting focal myeloma lesions.
MR imaging findings may not correlate directly with systemic disease markers.