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Clinically translated ischemic stroke genomics
1Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. meschia.james@mayo.edu
Stroke
|September 11, 2004
Summary
A family history of stroke increases stroke risk by 30%. Genetic factors for stroke remain significant throughout life, even in older adults, influencing risk and outcomes.
Area of Science:
- Genetics
- Neurology
- Epidemiology
Background:
- Family history of stroke is associated with a 30% increased risk.
- Stroke heritability varies by subtype, with cardioembolic stroke being least heritable.
- Genetic influence on stroke risk persists into late adulthood.
Purpose of the Study:
- To explore the genetic underpinnings of stroke risk and outcomes.
- To address challenges in stroke gene discovery due to complex phenotypes.
- To investigate genetic influences on intermediate phenotypes and therapeutic responses.
Main Methods:
- Analysis of cohort studies and twin studies on stroke family history.
- Focus on individual ischemic stroke subtypes for genetic analysis.
- Investigation of intermediate phenotypes like leukaraiosis for heritability.
Main Results:
- Genetic factors contribute significantly to stroke risk across the lifespan.
- Leukaraiosis exhibits high heritability (approximately 70%).
- Genes influence not only stroke risk but also post-stroke outcomes and drug response.
Conclusions:
- Genetics plays a crucial role in stroke etiology and progression.
- Stratifying by stroke subtype and intermediate phenotypes aids gene discovery.
- Future research should consider genetic influences on treatment efficacy and recovery.