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Updated: Aug 22, 2026
Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Construction of a transplantable tissue-engineered artificial peritoneum
H Kuga1, T Morisaki, K Nakamura
1Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Background:
Peritoneal defects lead to serious postoperative problems. Thus the development of physiological material to cover peritoneal defects is very desirable.
Aim:
The aim of this study was to develop a transplantable artificial peritoneum.
Method:
The artificial peritoneum consisted of collagen gel, fibroblasts, and mesothelial cells, and histological features were analyzed. The artificial peritoneum at the site of a peritoneal defect in the rat was transplanted to the abdominal wall.
Results:
Histological examination revealed that the artificial peritoneum consisted of a flat mesothelial monolayer upon a stromal matrix. All transplanted artificial peritoneums adapted well to the host and prevented severe adhesion.
Conclusion:
Our artificial peritoneum may be a useful transplantable bioengineered material for repair of surgical peritoneal defects.
