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Pharmacokinetics-pharmacodynamics during drug development--an example from Servier: ivabradine
Christian Laveille1, Roeline Jochemsen
1Institut de Recherches Internationales Servier, Courbevoie, France. christian.laveille@fr.netgrs.com
Abstract:
A short introduction to the principles of pharmacokinetic-pharmacodynamic (PK-PD) modelling and population approaches is provided in this article. The importance of implementing these techniques in the drug development process is illustrated by an example from experience at the Servier International Research Institute. This example demonstrates how the use of PK-PD modelling can rationalise the development process and save valuable time. Population approaches significantly contribute to the integration of PK-PD modelling into the different drug development phases by expanding the possibilities of application.
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