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Related Experiment Videos

Transient hypoglycemic abducens palsy.

Susanna Anhaus1, Raphael M Bonelli, Gerald Niederwieser

  • 1Department of Neurology, Hospital BHB Eggenberg, Graz, Austria.

Acta Medica Austriaca
|September 14, 2004
PubMed
Summary
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Peripheral neuropathy is rare in insulinoma patients. This case report details a unique instance of cranial nerve involvement, specifically abducens nerve paresis, in a patient with chronic hyperinsulinism.

Area of Science:

  • Endocrinology
  • Neurology

Background:

  • Insulinoma, a rare pancreatic tumor, causes hyperinsulinism and hypoglycemia.
  • Peripheral neuropathy is an infrequent complication of insulinoma, with only 32 cases reported since 1928.

Observation:

  • A 56-year-old woman with a decade-long history of severe hypoglycemic attacks due to insulinoma is presented.
  • The patient recently developed a 6-week-long paresis of the right abducens nerve.

Findings:

  • This case represents the first documented instance of cranial nerve affection in patients with insulinoma-associated peripheral neuropathy.
  • The findings suggest a potential, previously unreported neurological manifestation of chronic hyperinsulinism.

Implications:

  • Highlights the importance of considering cranial nerve palsies in the differential diagnosis of neurological symptoms in insulinoma patients.

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  • May prompt further research into the mechanisms linking hyperinsulinism and specific neurological deficits, including cranial nerve involvement.