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Related Experiment Videos

Heparin conjugated polylactide as a blood compatible material.

Kyoung Soo Jee1, Hyung Dal Park, Ki Dong Park

  • 1Department of Molecular Science and Technology, Ajou University, Suwon 442-749, Korea.

Biomacromolecules
|September 14, 2004
PubMed
Summary

Researchers created a new biodegradable polymer (PLA-heparin) by attaching heparin to polylactide. This material improves blood compatibility by reducing clotting, protein adsorption, and platelet adhesion for medical devices.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Biodegradable polymers like polylactide (PLA) are widely used in medical devices.
  • Enhancing the hemocompatibility of these materials is crucial for preventing adverse biological responses.
  • Heparin is a well-known anticoagulant and anti-adhesive agent.

Purpose of the Study:

  • To synthesize and characterize a novel heparin-conjugated biodegradable polymer (PLA-heparin).
  • To evaluate the hemocompatibility and bioactivity of the synthesized PLA-heparin conjugate.
  • To assess its potential for use in blood-contacting medical devices and tissue engineering.

Main Methods:

  • Direct coupling of heparin to polylactide (PLA) to form PLA-heparin.
  • Characterization of the PLA-heparin conjugate, including surface heparin content measurement.

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  • Evaluation of surface hydrophilicity, activated partial thromboplastin time (APTT) for clotting inhibition, and bioactivity of bound heparin.
  • Assessment of protein adsorption and platelet adhesion on PLA-heparin surfaces compared to control PLA.

    • Main Results:

    • Successfully synthesized and characterized PLA-heparin with a surface heparin content of 0.067 microg/cm2.
    • PLA-heparin exhibited increased hydrophilicity compared to pure PLA.
    • Activated partial thromboplastin time (APTT) was significantly prolonged for PLA-heparin, indicating anticoagulation.
    • The bioactivity of bound heparin was measured at 17.4% of free heparin.
    • Heparin conjugation suppressed protein adsorption and platelet adhesion.

    Conclusions:

    • The novel PLA-heparin conjugate demonstrates significantly improved hemocompatibility.
    • Bound heparin effectively inhibits coagulation, plasma protein adsorption, and platelet adhesion.
    • This heparin-conjugated biodegradable polymer shows promise for blood/tissue compatible implantable medical devices and tissue engineering applications.