Related Experiment Video
Updated: Aug 22, 2026
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
A quantitative and qualitative evaluation of LISA, a decision support system for chemotherapy dosing in childhood
Jonathan Bury1, Chris Hurt, Anindita Roy
1Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK. j.p.bury@sheffield.ac.uk
Objectives:
To assess the acceptability to clinicians of a web-based decision support system designed to assist with dosage adjustments during maintenance therapy for childhood Acute Lymphoblastic Leukaemia (ALL), and to evaluate the potential impact of the system on decision-making and dosage calculations.
Design:
Balanced-block crossover experiment with simulated cases; questionnaire study and semi-structured interviews.
Participants:
36 clinicians with differing experience in the management of ALL.
Interventions:
Subjects were asked to decide on appropriate levels of chemotherapy dosing for 8 simulated cases, 4 using the LISA decision support system, 4 using conventional paper-based records and guidance.
Main Outcome Measures:
Number of protocol-consistent dosage decisions made; time taken to manage each case; accuracy of dosage calculations; subjects' opinions as to whether or not they would use the system in practice. ADDITIONAL OUTCOME MEASURES: Functions subjects would like to see in an idealised system; subjects' satisfaction with the implementation of the functions provided by LISA; qualitative data on issues subjects felt would impact upon the successful deployment of the system.
