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Primary thyroid lymphoma associated with Graves' disease.

Yasuko Doi1, Aya Goto, Tsukasa Murakami

  • 1Noguchi Thyroid Clinic & Hospital Foundation, Beppu, Oita, Japan. doi@noguchi-med.or.jp

Thyroid : Official Journal of the American Thyroid Association
|September 14, 2004
PubMed
Summary

Thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is a rare complication in patients with Graves' disease. This case highlights the importance of investigating thyroid enlargement in Graves' disease patients for potential lymphoma.

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Area of Science:

  • Oncology
  • Endocrinology
  • Pathology

Background:

  • Graves' disease is an autoimmune disorder leading to hyperthyroidism.
  • Antithyroid drug therapy is a common treatment for Graves' disease.
  • Primary thyroid lymphoma is a rare malignancy of the thyroid gland.

Observation:

  • A 75-year-old woman with Graves' disease developed rapid, painless thyroid enlargement.
  • Ultrasonography and fine-needle aspiration biopsy revealed atypical lymphoid cells.
  • Gallium-67 scintigraphy showed thyroid-specific uptake.

Findings:

  • Histological, immunohistochemical, and flow cytometric analyses confirmed mucosa-associated lymphoid tissue (MALT) lymphoma.
  • The patient was treated with total thyroidectomy and radiation therapy for stage IE primary thyroid lymphoma.

Related Experiment Videos

  • This represents a rare instance of MALT lymphoma in a patient with Graves' disease.

    • Implications:

    • Enlargement of the thyroid in Graves' disease patients warrants careful evaluation for primary thyroid lymphoma.
    • Early detection and diagnosis are crucial for effective management of thyroid MALT lymphoma.
    • This case contributes to the limited literature on the association between Graves' disease and thyroid lymphoma.