Intraoral neuropathy
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Updated: Aug 16, 2026

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
Published on: September 29, 2017
1School of Dentistry, University of California, Los Angeles, 10833 LeConte Avenue, Room 10-157, Box 951668, Los Angeles, CA 90024, USA. rmerrill@ucla.edu
Abstract:
Chronic nonodontogenic toothache has been reported in the literature since the 1700s. This problem has followed a similar scenario since those first reports. The patient typically is misdiagnosed and then subjected to multiple unnecessary procedures, ultimately resulting in tooth extractions because of dentists and physicians being unaware of the existence of atypical odontalgia and other types of intraoral neuropathic pain that are treatable without sacrificing the teeth. This paper reviews the medications and procedures used to treat nonodontogenic toothache.
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