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[Lysophosphatidic acid: a "bioactive" phospholipid].

Jean-Sébastien Saulnier-Blache1

  • 1Inserm U.586, Institut Louis Bugnard, CHU Rangueil, 31404 Toulouse, France. saulnier@toulouse.inserm.fr

Medecine Sciences : M/S
|September 14, 2004
PubMed
Summary

Lysophosphatidic acid (LPA) is a bioactive lipid involved in cell growth and physiological processes. Targeting LPA receptors and metabolic enzymes offers potential therapeutic strategies for various diseases.

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Area of Science:

  • Lipid signaling
  • Cellular biology
  • Biochemistry

Context:

  • Lysophosphatidic acid (LPA) is a bioactive phospholipid with growth factor-like activities.
  • LPA plays roles in normal physiology (wound healing, vascular tone) and disease (atherosclerosis, cancer, obesity).

Purpose:

  • To review the role of bioactive lysophosphatidic acid (LPA) in physiological and pathological processes.
  • To highlight LPA receptors (LPA1-3) and metabolic enzymes as potential therapeutic targets.

Summary:

  • LPA mediates its effects by activating specific G-protein coupled receptors (LPA1-3), influencing intracellular signaling pathways.
  • Extracellular LPA is synthesized by soluble phospholipases (e.g., autotaxin) from precursors like phosphatidic acid.
  • LPA is found in extracellular fluids, bound to albumin, and released by cells like platelets and adipocytes.

Impact:

  • Understanding LPA's role is crucial for developing targeted therapies for diseases linked to its dysregulation.
  • LPA receptors and metabolic enzymes represent promising targets for pharmacological and transgenic interventions to modulate LPA's in vivo relevance.

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