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Methodological issues in epidemiologic studies using biologic markers.

B S Hulka1, B H Margolin

  • 1Department of Epidemiology, University of North Carolina, Chapel Hill 27599.

American Journal of Epidemiology
|January 15, 1992
PubMed
Summary
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Transitional epidemiologic studies integrate laboratory and field research using biologic markers. This approach enhances epidemiologic research by addressing unique challenges in study design and data analysis.

Area of Science:

  • Epidemiology
  • Biostatistics
  • Laboratory Science

Background:

  • Biologic markers are increasingly incorporated into traditional epidemiologic studies.
  • This integration necessitates a new research paradigm, termed "transitional epidemiologic studies."
  • Collaboration between laboratory and epidemiologic researchers is fundamental to this approach.

Purpose of the Study:

  • To define the goals and characteristics of transitional epidemiologic studies.
  • To present examples illustrating the application of biologic markers in epidemiology.
  • To highlight methodological considerations unique to these studies.

Main Methods:

  • Review of existing literature and case studies on transitional epidemiologic research.
  • Identification of key features, including sources of bias (misclassification, confounding).

Related Experiment Videos

  • Discussion of study design elements to mitigate biases and enhance data quality.

    • Main Results:

    • Transitional studies require careful consideration of sample size and variable transformation.
    • Sources of variability are more complex when incorporating biologic markers.
    • Examples demonstrate how biologic markers alter the methodological landscape of epidemiologic research.

    Conclusions:

    • Transitional epidemiologic studies represent an evolution in research methodology.
    • Effective implementation requires addressing specific challenges in study design and analysis.
    • This approach holds significant potential for advancing our understanding of disease etiology.